studies of cytotoxic potential of cucumis melo. linn fruit aqueous extract in prostate cancer cell lines pc-3 using mtt and neutral red assay

Authors

sibi perumbamkudiyil ittiyavirah asst. professor&head, dept. of pharmacologydepartment of pharmacology, university college of pharmacy, cheruvandoor campus, ettumanoor p.o, kottayam, kerala pin-686691,india

ann george

anju m santhosh

sudhi t kurian

abstract

the objective of the study was to evaluate thecytotoxic effects of aqueous fruit extract of cucumis melo in human prostate cancer cell line (pc-3) using mttand neutral red assays. the crude aqueous extract of c.melo was prepared by cold maceration method, filtered,concentrated and tested on pc-3 cell line. dose-dependent cytotoxic activitieswere exhibited by human prostate carcinoma pc-3 cell line. as the dose of theextract increased, the number of viable cells decreased. this confirms the anti-cancerand cytotoxic potential of the fruit of c.melo.

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Journal title:
iranian journal of pharmacology and therapeutics

جلد ۱۲، شماره ۱، صفحات ۲۴-۰

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